Stress Glucocorticoids Receptor Receptor Survival (Radiation) Ubiquitination Mdm2 nation ubiquitination Image removed for copyright considerations Oncogene. The Bcl-2 family roles in cell survival and Ubiquitination Bc|-2 oncogenesIs.2003Nov2422(53):8590-607 Ubiquitination Smac/Diablo Cytochrome c NEXB Degradation Ubiquitination Caspase-Dependent Apoptosis Pathway Figure by MIT OCW. After Yang and Xu, "Regulation of apoptosis the ubiquitous way " FASEB J 17(2003)790-799 cytochrome c Apaf-1 Death Receptor-ligand interactions Regulated by cytokines and hormones mitochondria Cell Injury initiator Caspases Na dama Execution Caspases Catabolism of cytoskeleton ELL DEATH nucleus Courtesy of Dr. Jeremy Hughes. Used with permission Source:"apoptosis,"http:/mWww.portfolio.mvm.ed.ac.uk/studentwebs/session2/group28/index.htmlImage removed for copyright considerations. Source: Fig.3 in Cory S, Huang DC, Adams JM. Oncogene. The Bcl-2 family: roles in cell survival and oncogenesis. 2003 Nov 24;22(53):8590-607. Figure by MIT OCW. After Yang and Xu, "Regulation of apoptosis: the ubiquitous way." FASEB J 17 (2003) 790-799. Courtesy of Dr. Jeremy Hughes. Used with permission. Source: "Apoptosis," http://www.portfolio.mvm.ed.ac.uk/studentwebs/session2/group28/index.html