Reversible anticholinesterases 1. Pharmacological effects binding to AChE, but slowly hydrolysis inhibiting AChE activity Properties of Effects stronger effect on skeletal muscles AChE(, ACh release, stimulating NM receptor effective on Gl tract and urinary bladder more polar and can not enter CNS relatively ineffective on CVS, glands, eye• 1. Pharmacological effects • binding to AChE, but slowly hydrolysis • inhibiting AChE activity • Properties of Effects • stronger effect on skeletal muscles • AChE (-), ACh release, stimulating NM receptor • effective on GI tract and urinary bladder • more polar and can not enter CNS • relatively ineffective on CVS, glands, eye Reversible anticholinesterases