Strategy to circumvent self-tolerance High-affinity, UTAAspecific Low-affinity, UTAA-specific A2. 1-restricte Peptide derived from UTAA CTL MHC A2. 1) Tumour cell Deleted from repertoire by Not deleted from repertoire but not effective in antitumour response 一感 Tg human MHC class UTAA' human A2.1h ow-affinity TCR UTAA-specific etion of high-a A2 1-restricted CTL Strategy to circumvent self-tolerance by T-cell receptor (TCR)gene transfer Expert Reviews in Molecular Medicine @2003 Cambridge University PressStrategy to circumvent self-tolerance