Immunologic factors the role of ige mediation The combination of allergen with specific IgE triggers the degranulation of the mast cells and eosinophils, resulting in release of mediators including leukotrienes C D, E, and the subsequent smooth muscle contraction edema of the mucosa increase of secretion, and finally stenosis of the bronchioles which all contribute to asthma. Total serum ige or specific serum Ige titer increase is seen in patients with asthma, indicating type I allergic reactions might be presentImmunologic factors the role of IgE mediation • The combination of allergen with specific IgE triggers the degranulation of the mast cells and eosinophils, resulting in release of mediators including leukotrienes C,D,E, and the subsequent smooth muscle contraction, edema of the mucosa, increase of secretion, and finally stenosis of the bronchioles ,which all contribute to asthma. Total serum IgE or specific serum IgE titer increase is seen in patients with asthma , indicating type I allergic reactions might be present