The Extracellular Matrices(ECMS Part I (summary of structure and function) Insoluble macromolecular networks Structure varies with organ; but different ECMs comprise few types of macromolecules(mostly collagen, elastin, proteoglycans )plus water(65%) ECM does not migrate, proliferate, synthesize proteins or contain DNA! Give and take of signals with cells. Ligands on ECM surface interact specifically with cell receptors (integrins) Partly determine the state of differentiation of cellsThe Extracellular Matrices (ECMs) Part I. (summary of structure and function) 5 ƒ Insoluble macromolecular networks. ƒ Structure varies with organ; but different ECMs comprise few types of macromolecules (mostly collagen, elastin, proteoglycans) plus water (65%). ƒ ECM does not migrate, proliferate, synthesize proteins or contain DNA! ƒ Give and take of signals with cells. Ligands on ECM surface interact specifically with cell receptors (integrins). ƒ Partly determine the state of differentiation of cells