Vascular Permeability Factor mRNA expression of vascular permeability factor increase in granular cell is related to COH Cytokines increased,including TNF,IL-1 and IL-2 Some of mediators of inflammation increased. including histamine and serotonin,which damaged the capillary and reduced angiotelectasis 10Vascular Permeability Factor • mRNA expression of vascular permeability factor increase in granular cell is related to COH • Cytokines increased, including TNF, IL-1 and IL-2 • Some of mediators of inflammation increased, including histamine and serotonin,which damaged the capillary and reduced angiotelectasis 10