3.7 The route and the characteristics of injection,inhalation,transdermal administration,and localadministration. 3.8 The significance ofplasma protein binding and physiological barriers. 3.9 P450 system. 3.10 Basic conceptsofpharmacokineticsand time-concentration curve. 3.11 Pharmacokinetic parameters including Tmax,Cmax,apparent volume ofdistribution(Vd),elimination rate constant(k),halftime(t1/2),area under the curve (AUC),bioavailability (F),and clearance(CL). 3.12 Etiological therapy and symptomatic therapy 4.Teaching Methods By using multimedia teaching method,off-line,on-line method,student-centered method and otherdiversified teaching methods,we inspire students to"leam with questions"and cultivate students'critical thinking ability. 5.Teaching Evaluation Questions: 1.What does first pass elimination mean? 2.According to the elimination kinetics of drugs,how to guide the rationaladministration? 3.How to use the index(Tmax,Cmax,AUC,F)to evaluate the quantity of the drugs? Chapter3 Drug Receptors Pharmacodynamics 1.Teaching Objectives 1.I To leam the types and definition of therapeutic effectsand adverse reactions. 1.2 To learn the definition and the significance ofdose-effect relationship. 1.3 To learn the basic conceptsof receptor kinetics,the types of receptors,the second messengers,and the significance of receptor regulation. 1.4 To learn the definition ofpharmacodynamics. 1.5 To understand the mechanismsofactions of drugs3.7 The route and the characteristics of injection, inhalation, transdermal administration, and local administration. 3.8 The significance of plasma protein binding and physiological barriers. 3.9 P450 system. 3.10 Basic concepts of pharmacokinetics and time-concentration curve. 3.11 Pharmacokinetic parameters including Tmax, Cmax, apparent volume of distribution (Vd), elimination rate constant (k), half time (t1/2), area under the curve (AUC), bioavailability (F), and clearance (CL). 3.12 Etiological therapy and symptomatic therapy. 4.Teaching Methods By using multimedia teaching method, off-line, on-line method, student-centered method and other diversified teaching methods, we inspire students to “learn with questions” and cultivate students’ critical thinking ability. 5.Teaching Evaluation Questions： 1. What does first pass elimination mean? 2. According to the elimination kinetics of drugs, how to guide the rational administration? 3. How to use the index (Tmax, Cmax, AUC, F) to evaluate the quantity of the drugs? Chapter3 Drug Receptors & Pharmacodynamics 1.Teaching Objectives 1.1 To learn the types and definition of therapeutic effects and adverse reactions. 1.2 To learn the definition and the significance of dose-effect relationship. 1.3 To learn the basic concepts of receptor kinetics, the types of receptors, the second messengers, and the significance of receptor regulation. 1.4 To learn the definition of pharmacodynamics. 1.5 To understand the mechanisms of actions of drugs