Classic of Phenotypic screening Iterative evolution process Conception A lead compd Test feedback A picture of ppropriate Synthesis bioassay Bioassay structure activity Unmet medical evaluation relationship need Active in least 3 /5 authentic exo-vivo or in vivo pharmacological models purpose? or When fit for its Judgment E xperience Workup Creativity Imagination Aesthetic intuition A concept-driven projectClassic of Phenotypic screening Conception A lead compd Appropriate bioassay Unmet medical need Iterative evolution process Synthesis Bioassay evaluation Test feedback A picture of structure￾activity relationship Active in least 3/5 authentic exo-vivo or in vivo pharmacological models When Fit for its purpose? Judgment Experience Imagination Aesthetic intuition —— A concept-driven project Workup Creativity When Fit for its purpose? Judgment Experience Imagination Aesthetic intuition 5