Perampane 右F.° Mechanism of action Non-competitive aMpa glutamate receptor 00 antagonist Anti-seizure effects should still be maintained even when glutamate concentrations are high · Pharmacokinetics 95% protein bound to albumin and al-acid glycoprotein Metabolized by cyP3A4 and CYP3A5 Half-life= 105 hours ¨·| interactions Decreases levonorgestrel KENTUCKY College of PharmacyPerampanel • Mechanism of action – Non-competitive AMPA glutamate receptor antagonist • Anti-seizure effects should still be maintained even when glutamate concentrations are high • Pharmacokinetics – 95% protein bound to albumin and α1-acid glycoprotein – Metabolized by CYP3A4 and CYP3A5 – Half-life = 105 hours • Interactions – Decreases levonorgestrel