HLA Class I and ll Molecules Have a Distinct Structure and Function .Binds 8-10mers ·Binds13-25mers .Expressed on most .Expressed on APCs, Nucleated cells Macs,B cells,activated .Presents Cytosolic T cells Proteins to CD8+T cells .Presents Vesicular Proteins to CD4+T cells 02 a1β1 B2 02 B2 ClassI Class ll BDC2 3 1 2 1 2 1 2 •Binds 8-10mers •Expressed on most Nucleated cells •Presents Cytosolic Proteins to CD8+ T cells •Binds 13-25mers •Expressed on APCs, Macs, B cells, activated T cells •Presents Vesicular Proteins to CD4+ T cells Class I Class II HLA Class I and II Molecules Have a Distinct Structure and Function BDC