Prioritize problems Establish review team and/or guideline panel Define questions to be addressed (varches.soleetoror Cuvcon and analysi (Re)assess the relative importance of outcomes Prepare an evidence profile GRADE An mnt of the quidence tor och outcome A summary of the findings Assess tne ovoaior evidence on the)and trengh of the Draft the systematic review or guideline Consult with stakeholders and/or external peer reviewers Disseminate the review or guideline Update review or guideline when needed Adapt guideline,if needed Prioritize recommendations for implementation Implement or support implementation of the quideline Evaluate the impact of the guideline and implementation strategies Update the systematic review and guideline