3.0 Images Highlighting Pixels with Low Values of Effective T2 Thin-slice, T2-weighted coronal images demonstrate increased distribution of pixels with short effective T2(here less than 46 msec)in brain of dementia patient as compared to normal volunteer To validate potential of brain iron of biomarker for ad or other ndds it is necessary to verify iron as causative factor in producing the low T2 pixels(cadaver brain studies ollect 3T MR data on patients and age-matched controls develop image post-processing techniques to quantify anatomical and statistical characteristics of low T2 pixelsG e n o m i c s a n d M o l e c u l a r I m a g i n g 3.0 T Images Highlighting Pixels with Low Values of Effective T2 Volunteer Dementia Patient Thin-slice, T2 -weighted coronal images demonstrate increased distribution of pixels with short effective T2 (here less than 46 msec) in brain of dementia patient as compared to normal volunteer. To validate potential of brain iron of biomarker for AD or other NDDs it is necessary to: • verify iron as causative factor in producing the low T2 pixels (cadaver brain studies). • collect 3T MR data on patients and age-matched controls. • develop image post-processing techniques to quantify anatomical and statistical characteristics of low T2 pixels