1920年发现BCG( Bacillus calmette-Guerin) Calmette guerin (1906-1921) M. bovis: low toxicity 1921 first iniection 1930 a disaster slowed public acceptance of the vaccine ■1945 worldwide used The most popular vaccine BcG:牛型结核杆菌(有毒株) 胆汁甘油-马铃薯培养 13年,230次传代 减毒株(BcG) 5/3/2016 Mycobacteria s lecture for MD students5/3/2016 Mycobacteria-Junqi's Lecture for MD students 11  Calmette & Guérin (1906-1921)  M. bovis; low toxicity  1921 first injection  1930 a disaster slowed public acceptance of the vaccine  1945 worldwide used  The most popular vaccine 1920年发现BCG (Bacillus Calmette-Guérin ) BCG：牛型结核杆菌（有毒株） 胆汁-甘油-马铃薯培养 13年，230次传代 减毒株（BCG）