Overall effect of determining phase in all four families Add increment of logo(2)=0.301 to each familys LOD score X LOD.oG(families 1, 2, 3, 4: all phased) X LODo.06(families 1, 2, 3, 4:unphased)+4 log10(2) =2001+40301)=3205 Publish What if we had not been able to obtain samples from any grandparents Try more markersOverall effect of determining phase in all four families:
LOD0.06 (families 1,2,3,4: all phased) =
LOD0.06 (families 1,2,3,4: unphased) + 4 log10 (2) = 2.001 What if we had not been able to obtain samples from any grandparents? Try more markers Publish! Add increment of log10(2) = 0.301 to each family’s LOD score. + 4 (0.301) = 3.205