上泽充通大￥ Shanghai Jiao Tong University Major groups of antibiotics(2) Macrolide antibiotics大环内脂类 Structure erythromycin,oleandomycin,spiramycin,tylosin 素，竹桃霉素，螺旋霉素，泰乐菌素 o inhibit protein synthesis at the 50S subunit of the ribosome Tetracyclines四环素类 Structure broad spectrum(act on both G+and G-bacteria) inhibit protein synthesis at the 30S subunit of the ribosome Shanghai Jiao Tong UniversityShanghai Jiao Tong University Macrolide antibiotics 大环内脂类 • erythromycin, oleandomycin, spiramycin, tylosin红霉 素,竹桃霉素,螺旋霉素,泰乐菌素 • inhibit protein synthesis at the 50S subunit of the ribosome Tetracyclines 四环素类 • broad spectrum (act on both G+ and G- bacteria) • inhibit protein synthesis at the 30S subunit of the ribosome Major groups of antibiotics (2) Structure Structure