天然药（产）物化学一 天然药物化学的魅力 一个充满魅力的领域？ u find them? 史清文教授 Nature is friendly?What can you do with them ature is healthy?Why do we care so much? http://202.206.48.73/tryw1/default.asp Where Chemistry and Biology Meet? The Chemistry Universe 天然产物化学 C.H.O.N.PF.Cl and MW500? Chemistry 片益 天然产物在药物发现中的作用 How are drugs discovered and developed Nature is one big medicine cabinet by Source ( SM:NP 药物研发一多学科系统工程 1 天然药物化学的魅力 史 清 文 教授 药学院天然药物化学教研室405室 QQ: 46897262 Mobile: 13643389897 http://202.206.48.73/tryw1/default.asp What are they? Where can you find them? What can you do with them? Why do we care so much? 天然药(产)物化学— 一个充满魅力的领域？ Nature is good? Nature is green? Nature is friendly? Nature is healthy? Where Chemistry and Biology Meet ? Chemistry Biology 天然产物化学 All Life Is Chemistry and Biology 天然产物作为化学和生物学之间一个天然的通道，是大自然经过漫长 的筛选和进化选择出来的，天然产物的结构与功能研究将对新药发现、对 于生命科学的认识、探索药物作用机制具有重要科学意义。 The Chemistry Universe Nature has compounds at hand that have the potential to treat and possibly also prevent the prominent diseases of modern societies. 天然产物在药物发现中的作用 n All small molecule new chemical entities by Source ( 01/1981- 06/2006) N: Natural product ND: Semi-synthetic NP S*: Made by total synthesis, but the pharmacophore from NP NM: NP mimic J Nat Prod 2007,70,461 Nature is one big medicine cabinet Newman D. J. 药物研发—多学科系统工程 How are drugs discovered and developed?