Toxic Mechanism Electrophilic chemical Electrophilic metabolites substances (from metabolism) Path I Path II Reactions with nucleophiles Reactions with nucleophiles Of non-defensive cellular With defensive system Molecules DNA RNA etc excretion toxicityToxic Mechanism Electrophilic chemical substances Electrophilic metabolites (from metabolism) Reactions with nucleophiles With defensive system Reactions with nucleophiles Of non-defensive cellular Molecules, DNA, RNA, etc excretion toxicity Path I Path II