C. Anencephaly D. Polymelia EIn 4. Marfan syndrome is a genetic disorder of human connective tissue. Which gene has been found to be associated with the Pathogenesis of Marfan Syndrome? A FBNI B. SHH C MAPK 14 D. PITXI E ERK2 5. Each of the following have been observed as mechanisms resulting in the activation of a proto-oncogene EXCEPt A. Amplification of an oncogene as small, sub-chromosomal fragments( double B Capture of the oncogene sequence by a retrovirus C. a point mutation altering the function of the oncogene protein product D. Inactivation of an oncogene by telomerase activity E. a chromosome translocation fusing portions of the oncogene and another cellular gene 6. Patients with familial retinob lastoma carry a germline mutation in one copy the rb gene. Potential mechanisms for inactivation of the other allele in a retinoblastoma tumor arising in one of these patients include B. Loss of the normal chromosome 13 C. Mitotic crossing over D. All of the above E. None of the above 7. The functions which have been identified for the proteins expressed by cellular proto-oncogenes include all of the following EXCEPt A enzyme involved in DNA mismatch repair B transcription factor C growth factor D. component of a signal transduction pathway E. growth factor receptorC. Anencephaly D. Polymelia E. Iniencephaly 4. Marfan syndrome is a genetic disorder of human connective tissue. Which gene has been found to be associated with the Pathogenesis of Marfan Syndrome? A. FBN1 B. SHH C. MAPK14 D. PITX1 E. ERK2 5. Each of the following have been observed as mechanisms resulting in the activation of a proto-oncogene EXCEPT: A. Amplification of an oncogene as small, sub-chromosomal fragments (double minutes) B. Capture of the oncogene sequence by a retrovirus C. A point mutation altering the function of the oncogene protein product D. Inactivation of an oncogene by telomerase activity E. A chromosome translocation fusing portions of the oncogene and another cellular gene 6. Patients with familial retinoblastoma carry a germline mutation in one copy of the Rb gene. Potential mechanisms for inactivation of the other allele in a retinoblastoma tumor arising in one of these patients include: A. An independent point mutation B. Loss of the normal chromosome 13 C. Mitotic crossing over D. All of the above E. None of the above 7. The functions which have been identified for the proteins expressed by cellular proto-oncogenes include all of the following EXCEPT: A. enzyme involved in DNA mismatch repair B. transcription factor C. growth factor D. component of a signal transduction pathway E. growth factor receptor