Table 3.C2 deficiencies Patient Patient Patient Patient Patient Nr.1 Nr.2 Nr.3 Nr.4 Nr.5 Sex Female Female Female Female Female Clinical No clinical Meningitis in Neonatal Girl died at the Otitis, course manifestation newborn age infection age 1 month sinusitis, due to recurrent meningitis meningitis Laboratory IgG,lgA个个， IgG,lgA↑， IgG↑，lgA IgG,IgG1-3 IgG,IgA,IgM investigatio IgE↑，c3,C4 IgM normal, not IgM,IgA 1gG1-4 normal, 1gE个，C3,C4 detecable, ↑，C3,C4 normal C3. C2↓↓，CH1o0 normal, IgM normal, normal C4 normal, normal CH100 C3,C4 CH100W CHm女 Genotypisat C2180/152 02r83152 N8Emal, Not Dereyon 28 ion 28bp 28bp Serformed performed bp not deletion deletion normal verified Therapy Antimicrobial Antimicrobial Antimicrobial Antimicrobial drugs drugs,plasma drugs drugs, vaccciination Pneumokok, Haemofilus, Meningokok Table 3. C2 deficiencies Patient Nr.1 Patient Nr.2 Patient Nr.3 Patient Nr.4 Patient Nr.5 Sex Female Female Female Female Female Clinical course No clinical manifestation Meningitis in newborn age Neonatal infection Girl died at the age 1 month due to meningitis Otitis, sinusitis, recurrent meningitis Laboratory investigatio n IgG, IgA, IgE , C3, C4 normal, C2, CH100 normal IgG, IgA, IgM normal, IgE , C3,C4 normal, CH100 normal IgG , IgA not detecable, IgM normal, C3,C4 normal, CH100 normal IgG, IgG1-3 , IgM, IgA , C3,C4 normal CH100  IgG, IgA, IgM IgG1-4 normal, C3, C4 normal, CH100  Genotypisat , C2  ion C2 180/152 28 bp deletion C2 180/152 28 bp deletion Not performed Not performed Deletion 28 bp not verified Therapy - Antimicrobial drugs Antimicrobial drugs, plasma Antimicrobial drugs Antimicrobial drugs, vaccciination Pneumokok, Haemofilus, Meningokok