Mutation random mutation rays (UV NTG >Cell fusion protoplast fusion hybridoma technique monoclonal anitibody >Genetic engineering >Extremphilic organisms pH、temperature、Salt、pressure➢ Mutation random mutation rays （UV ） NTG ➢ Cell fusion protoplast fusion hybridoma technique monoclonal anitibody ➢ Genetic engineering ➢ Extremphilic organisms pH、temperature、salt、 pressure