MHC Molecules MHC molecules may be viewed as a third set of recognition molecules for Ag in the immune response, in addition to the Ag-specific T-cell and B-cell receptors. Important in rejection of tissues(mice studies) Every vertebrate species has MHC genes and products Transplantation rejection responses are dominated by T cells MHC plays a central role in T cell interactions>both T cell development in the thymus and response of T cells to Ag MHC restriction of T-cell responsesMHC Molecules ◼ MHC molecules may be viewed as a third set of recognition molecules for Ag in the immune response, in addition to the Ag-specific T-cell and B-cell receptors. ◼ Important in rejection of tissues (mice studies) ◼ Every vertebrate species has MHC genes and products ◼ Transplantation rejection responses are dominated by T cells ◼ MHC plays a central role in T cell interactions → both T cell development in the thymus and response of T cells to Ag ◼ MHC restriction of T-cell responses