Quantitative description of healing processes Initial wound area is Ao Wound eventually closes up spontaneously. Final area is Af Final wound area is distributed among fractions that closed by contraction ( %C), scar formation %s) or regeneration (%R) This is the configuration of the final state Wound closure rule c+S+R=100Quantitative description of healing processes • Initial wound area is A o • Wound eventually closes up spontaneously. Final area is A f . • Final wound area is distributed among fractions that closed by contraction (% C), scar formation (%S) or regeneration (% R). • This is the configuration of the final state. • Wound closure rule: C + S + R = 100