Maxam-Gilbert Sequencing The Maxam-Gilbert sequencing method follows a very different strategy. Instead of synthesizing DNA in vitro and stopping the synthesis reactions with chain terminators,this method starts with full length,end-labeled DNA and cleaves it with base-specific reagentsMaxam-Gilbert Sequencing The Maxam-Gilbert sequencing method follows a very different strategy. Instead of synthesizing DNA in vitro and stopping the synthesis reactions with chain terminators, this method starts with full length, end-labeled DNA and cleaves it with base-specific reagents