Conway Niu 08301016018 Medical Genetics Summary paper: Schizophrenia purposeless moveme nts (positive symptom). There are also others that are related, such as undifferentiated and residual types, as well as post-schizophrenic depression and simple schizophre Individuals who are at highest risk for schizophrenia are those with a family history of the disorder or a family history of any psychotic disorder Prenatal problems and drug and alcohol issues abso play a role. Twin studies have shown that individuals with a monozygotic twin who has the disorder is most like ly to deve lop it The age of onset is usually late adolescence and rly adulthood Schizophrenia is said to be caused by a few main factors: dopamine imbalance, genetics prenatal and early environment and neurobiology. Genetics, our focus, must be considered in conjunction with environmental factors and is usually multifactorial meaning that it is caused by interactions of several genes In a series of studies published in the july 2009 issue of Nature show that there is a chromosome hot spot"on the extended MHc region on the short arm of chromosome 6 otherwise known as chromosome 6p22. 1. the studies showed that there was significant association between single nucleotide polymormor phisms in the mhc region on chromosome 6 Another study further discussed the hot spot with relation to copy number variations and their inheritance; this showed that risk alleles for schizophrenia existed on chromosome 6. Only a fraction of the information that is yet to be explored were given in this presentation and was meant to be a primer on the genetic factors of schizophren ia. However at the same time, this presentation allowed us to apply some of the basic information learned within lectures to real-life issuesConway Niu 08301016018 Medical Genetics Summary paper: Schizophrenia purposeless movements (positive symptom). There are also others that are related, such as undifferentiated and residual types, as well as post-schizophrenic depression and simple schizophrenia. Individuals who are at highest risk for schizophrenia are those with a family history of the disorder, or a family history of any psychotic disorder. Prenatal problems and drug and alcohol issues also play a role. Twin studies have shown that individuals with a monozygotic twin who has the disorder is most likely to develop it. The age of onset is usually late adolescence and early adulthood. Schizophrenia is said to be caused by a few main factors: dopamine imbalance, genetics, prenatal and early environment, and neurobiology. Genetics, our focus, must be considered in conjunction with environmental factors, and is usually multifactorial, meaning that it is caused by interactions of several genes. In a series of studies published in the July 2009 issue of Nature show that there is a chromosome “hot spot” on the extended MHC region on the short arm of chromosome 6, otherwise known as chromosome 6p22.1. The studies showed that there was significant association between single nucleotide polymormorphisms in the MHC region on chromosome 6. Another study further discussed the hot spot with relation to copy number variations and their inheritance; this showed that risk alleles for schizophrenia existed on chromosome 6. Only a fraction of the information that is yet to be explored were given in this presentation, and was meant to be a primer on the genetic factors of schizophrenia. However, at the same time, this presentation allowed us to apply some of the basic information learned within lectures to real-life issues