ORGANIC CHEMISTRY Chapter 15 NH NH NH HNO3 HNO H2SO4 H2SO 4 NO An amino group or hydroxyl group can be protected (and turned into a moderately activating group) by acetylation NH, NHCOCH CH3 COCI or(CH3 CO)2o Base P rotecting acylation groups OH COCH CH3COCI or(CH3co)20 Base Department of Chemistry, Xiamen UniversityORGANIC CHEMISTRY Department of Chemistry, Xiamen University Chapter 15 ¾ An amino group or hydroxyl group can be protected (and turned into a moderately activating group) by acetylation. Protecting groups NH2 CH3COCl or (CH3CO)2O NHCOCH3 OH OCOCH3 Acylation Base CH3COCl or (CH3CO)2O Base NH2 HNO3 NH3 H2SO4 NH3 HNO3 H2SO4 NO2