Induced fit- Dan Koshland. jr How- ever, it is now evident that the shapes of the active sites of many enzymes are markedly modified by the binding of substrate, as was postulated by Daniel E. Koshland, Jr, in 1958. The active sites of these enzymes assume shapes that are complementary to that of the substrate only after the substrate is bound. This process of dynamic recognition is called induced fit(Figure 8-14)Induced Fit — Dan Koshland, Jr