Blood Gastric lumen Epithelial cell上皮细胞 Sucralfate Cytoprotective effect Mucus Mucus ⊕ Bicarbonate Bicarbonate PG Misoprostol Parietal cell壁细胞 PG cAMP ⊕ ⊕ Protein kinases Histamine ⊕ 质子泵 H+/ Cimetidine, Lansoprazole and famotidine, omeprazole ATPase Aluminum and and ranitidine magnesium K+ hydroxides and calcium ⊕ Acetylcholine →M3 Ca2+ carbonate Gastrin- G质子泵 壁细胞 上皮细胞