Synthetic Methodology 3 &s p-Cationic Cyclization: a Biomimetic approach, complex polycyclic array in a single step Squalene oxide H H HO Dammaradienol H HO e Stereospecific es At one full swoop Four carbocyclic rings at the expense of single oxirane ring, and six contiguous stereogenic centers are created! e Triple bond participate in cyclization to form five membered ringSynthetic Methodology 3 ? p-Cationic Cyclization: a Biomimetic approach, complex polycyclic array in a single step. ? Stereospecific. ? At one full swoop, Four carbocyclic rings at the expense of single oxirane ring, and six contiguous stereogenic centers are created ! ? Triple bond participate in cyclization to form five membered ring. H O Squalene oxide HO H H H HO H Dammaradienol H