Pathogenicity No invasiveness, toxemia s, retrograde transport exogenous Inrection to(CNS) produces two exotoxins tetanolysin, and delitescence: a few tetanospasmin(a kind of days to several neurotoxin, toxicity strong) weeks The actions of 8 The two animal tetanospasmin are species most complex and involve three susceptible to this components of the nervous system: central toxemia are horses motor control, autonomic and humans ■ function and the neuromuscular junctionPathogenicity ◼ No invasiveness; toxemia (exogenous infection） ◼ produces two exotoxins: tetanolysin, and tetanospasmin(a kind of neurotoxin, toxicity strong) ◼ The actions of tetanospasmin are complex and involve three components of the nervous system: central motor control, autonomic function, and the neuromuscular junction. ❖ retrograde transport to (CNS) ❖ delitescence：a few days to several weeks ❖ The two animal species most susceptible to this toxemia are horses and humans