Ill. simple acid-base disturbance 1. meta bolic acidosis concept: the primary disturbance is a decrease of [ Hco 3 in the arterial plasma 1) cause and pathogenesis lactic acidosis: hypoxia, diabetes liver disease ketoacidosis: diabetes. starvation ① metabolic acidosis in severe renal failure: fixed acids t increased AG salicylic acid acid 1 poisoning. intake food IⅢ. simple acid-base disturbance 1. metabolic acidosis concept: the primary disturbance is a decrease of [HCO- 3] in the arterial plasma 1) cause and pathogenesis lactic acidosis: hypoxia, diabetes liver disease ketoacidosis: diabetes, starvation ① metabolic acidosis in severe renal failure: fixed acids increased AG salicylic acid acid poisoning: intake food