ORGANIC CHEMISTRY Chapter 12 12.1b Reactions of Carbonyl Compounds with nucleophiles o From a synthetic of view, one of the most important reactions of carbonyl compounds is one in which the compound undergoes nucleophilic addition l+C=0 Nu-c-o Nu o Two im portant nucleo i hiles o Hydride ions(h) from NaBHa or LialH4 o Carbanions(rch2)from RLi or RMgx Department of Chemistry, Xiamen UniversityORGANIC CHEMISTRY Department of Chemistry, Xiamen University Chapter 12 12.1B Reactions of Carbonyl Compounds with Nucleophiles From a synthetic of view, one of the most important reactions of carbonyl compounds is one in which the compound undergoes nucleophilic addition. C O Nu δ δ + Nu C O Two important nucleophiles: Hydride ions (Hˉ) from NaBH4 or LiAlH4 Carbanions (RCH2 ˉ) from RLi or RMgX