Diabetes -Insulin Discovered in 1921 by banting and Best Consist of a b chains linked by 2 disulfide bonds (plus additional disulfidein a +A=2lamino acids b=30 amino acids NHrs NHz NH NEI Gily-Ilou-val-Glu-Glu-Cy-Cy-Thr-Ser-llen-Cy-Ber-Leu-Try-Glu-Leu-Glu-Aap-Tyr-Cy-Asp 23456 8910111213141516171819/21 NH: NLa e-TyI-Thr-Pro-Lyg-Thr 1 8, 9, 10 and B so Phe-Val-Asp-Glu-His-Leu-Cy-Gly-Ser-His-Leu-Val-Glu-Ala-Len-Tyr-Leu-Val-Cy-Gly-Glu-Art-Gly-PI 12345078910112111516118102n222232425262228230A Al Sperm whale Rabbit HorseDiabetes - Insulin ◼ Discovered in 1921 by Banting and Best ◼ Consist of A & B chains linked by 2 disulfide bonds (plus additional disulfide in A) ~ ~ A = 21amino acids B = 30 amino acids