(2).The effect of Growth factors 1. EGF: mitogenic for keratinocytes and Fb 2. PDGF: chemotactic for PMNs Mo. Fb. SMC: stimulates production of MMPs, Fn, HA, angiogenesis and wound contraction 3. bFGF: chemotactic for Fb, mitogenic for Fb and keratinocytes stimulates keratinocyte migration, angiogenesis, matrix deposition 4. HGF: stimulates proliferation of epithelial and endothelial cells 5. KGF: stimulates keratinocyte migration, proliferation and differentiation 6. TGF-B: chemotactic for PMNS, Mo, Lymphocytes, Fb, SMC; stimulates TIMP synthesis, keratinocyte migration, angiogenesis and fibroplasia; inhibits production of MMPs and keratinocyte proliferation 7. IL-1: chemotactic for PMNs: stimulation of MMP-I synthesis 8. TNF: activates Mop, regulates other cytokines(2).The effect of Growth factors 1. EGF: mitogenic for keratinocytes and Fb 2. PDGF: chemotactic for PMNs, MΦ, Fb, SMC; stimulates production of MMPs, Fn, HA, angiogenesis and wound contraction 3. bFGF: chemotactic for Fb, mitogenic for Fb and keratinocytes, stimulateskeratinocyte migration, angiogenesis, matrix deposition 4. HGF: stimulatesproliferation of epithelial and endothelial cells 5. KGF: stimulateskeratinocyte migration, proliferation and differentiation 6. TGF-: chemotactic for PMNs, MΦ, Lymphocytes, Fb, SMC; stimulatesTIMP synthesis, keratinocyte migration, angiogenesis and fibroplasia; inhibitsproduction of MMPs and keratinocyte proliferation 7. IL-1: chemotactic for PMNs; stimulation of MMP-1 synthesis 8. TNF: activatesMΦ, regulates other cytokines