MEVASTATIN LOVASTATIN SIMVASTATIN PRAVASTAT OH HIC 小人hC CH3 H3C CH3 CH3 H3C 'H CH H3C FLUVASTATIN ATORVASTATIN CERIVASTATIN CH3)2CH ①叉叉∞m CH(CI H3)2 Hco 2 (CH3)2HC CH(CH3) Reaction Catalyzed by HMG-CoA Reductase HMG COA HO CH3 CO0 NADPH +H COo NADPH+H Fcoo- reductase inhibitors HMG-COA Intermediate Mevalonate