Autophagy Autophagosome a double membrane bound compartment that engulfs cytosol and degrades the cytoplasmic contents Large: 400-1500 nm May originate from eR or from fusion of lipid-containing vesicles that form sequestration crescentAutophagy ◼ Autophagosome: A double membrane bound compartment that engulfs cytosol and degrades the cytoplasmic contents. ◼ Large: 400-1500 nm ◼ May originate from ER or from fusion of lipid-containing vesicles that form ‘sequestration crescent’