O Med Sci Monit, 2005: 115 M133-38 WWW MEDSCIMONIT COM PMD:15874903 2005 02.03 X-ray diffraction-enhanced imaging of uterine 20050 leiomyomas Authors'Contribution: Chenglin Liu1. 2,34B(D, Yuan Zhang n, Xinyi Zhang. 3.BcD, Wentao Yang d A Study Design B Data Collection Weijun Peng d, Daren Shi, Peiping Zhu 5B, Yulian Tiana, Wanxia Huang 5t c Statistical Analysis D 1 Synchrotron Radiation Research Center of Fudan University, Shanghai, China 2 Physics Department of Yancheng Normal College, Yancheng Jiangsu, China E Manuscript Preparation3Physics Department, Surface Physics Laboratory(National Key laboratory)of Fudan University, Shanghai, Chir G Funds Collection Cancer Hospital, Medical Center of Fudan University, Shanghai, China s Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, Source of support: This work was supported by the National Natural Science Foundation of China (N0.10105002) Summary Background: The purpose of this study was to investigate the microstructures of a uterine leiomyoma using a synchrotron-based imaging technique Material/Methods: The tissues of different regions of a uterine leiomyoma were imaged using X-ray diffraction-en- hanced imaging Results: Compared with optical microscopy and conventional X-ray, X-ray diffraction-enhanced imaging an show not only the surface, but also the internal structure of organs or soft tissues with better contrast. Internal hyaline degeneration and the cavum of liquefied uterine leiomyomas are shown very clearly. Some microstructures, such as the myomatous burble, rupture and conglomeration of muscle fiber, and the cavum resulting from red degeneration, can be displayed in X-ray diffrac- tion-enhanced images. These microstructures can show the developmental progress of necrosis in uterine leiomyomas and indicate their potential canceration Conclusions: X-ray diffraction-enhanced imaging can clearly show intemal microstructures of uterine leiomyom making the complex procedure of doing this with a large number of pathology slices avoidable key words: uterine leiomyomas.microstructures X-ray diffraction-enhanced imaging synchrotron radiation Full-textPdf:http://www.medscimONitcom/Pub/vOl1_1/no_5/7006.pdf Word count: 2456 Figures:5 References Authors address: Xinyi Zhang, Synchrotron Radiation Research Center of Fudan University, Shanghai 200433, China -mail:xy-zhang@fudan.edu.cn Current Contents/Clinical Medicine. SCI Expanded. ISI Alerting System Index Medicus/MEDLINE.EMBASE/Excerpta Medica. Chemical Abstracts. Index Copernicus MT33X-ray diffraction-enhanced imaging of uterine leiomyomas Chenglin Liu1,2,3ABCDEF, Yuan Zhang1BF, Xinyi Zhang1,3ABCDEFG, Wentao Yang4CD, Weijun Peng4D, Daren Shi4D, Peiping Zhu5B, Yulian Tian5B, Wanxia Huang5B 1 Synchrotron Radiation Research Center of Fudan University, Shanghai, China 2 Physics Department of Yancheng Normal College, Yancheng Jiangsu, China 3 Physics Department, Surface Physics Laboratory (National Key laboratory) of Fudan University, Shanghai, China 4 Cancer Hospital, Medical Center of Fudan University, Shanghai, China 5 Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China Source of support: This work was supported by the National Natural Science Foundation of China (No. 10105002) Summary Background: The purpose of this study was to investigate the microstructures of a uterine leiomyoma using a synchrotron-based imaging technique. Material/Methods: The tissues of different regions of a uterine leiomyoma were imaged using X-ray diffraction-en￾hanced imaging. Results: Compared with optical microscopy and conventional X-ray, X-ray diffraction-enhanced imaging can show not only the surface, but also the internal structure of organs or soft tissues with better contrast. Internal hyaline degeneration and the cavum of liquefi ed uterine leiomyomas are shown very clearly. Some microstructures, such as the myomatous burble, rupture and conglomeration of muscle fi ber, and the cavum resulting from red degeneration, can be displayed in X-ray diffrac￾tion-enhanced images. These microstructures can show the developmental progress of necrosis in uterine leiomyomas and indicate their potential canceration. Conclusions: X-ray diffraction-enhanced imaging can clearly show internal microstructures of uterine leiomyomas, making the complex procedure of doing this with a large number of pathology slices avoidable. key words: uterine leiomyomas • microstructures • X-ray diffraction-enhanced imaging • synchrotron radiation Full-text PDF: http://www.MedSciMonit.com/pub/vol_11/no_5/7006.pdf Word count: 2456 Tables: — Figures: 5 References: 16 Author’s address: Xinyi Zhang, Synchrotron Radiation Research Center of Fudan University, Shanghai 200433, China, e-mail: xy-zhang@fudan.edu.cn Authors’ Contribution: A Study Design B Data Collection C Statistical Analysis D Data Interpretation E Manuscript Preparation F Literature Search G Funds Collection Received: 2005.02.02 Accepted: 2005.02.03 Published: 2005.05.05 MT33 Diagnostics and Medical Technology © Med Sci Monit, 2005; 11(5): MT33-38 WWW.MEDSCIMONIT.COM PMID: 15874903 MT Current Contents/Clinical Medicine • SCI Expanded • ISI Alerting System • Index Medicus/MEDLINE • EMBASE/Excerpta Medica • Chemical Abstracts • Index Copernicus