GASTRIC FACTORS Incroased vagal actlt DUODENAL FACTORS Parietal cel H.Pylori Sensitivity of mucosa to acid injury ncreased sensitv Decreased mucosal stimulators of HCl HCOs secretion secretion (0.g. gastrin,histamine) Rapid gastric PEPTIC ULCER emptying Hyperacidification duodenal bulb Decreased retrogrado 胃、十二指肠结构及溃疡病病 motility impairs neutralization by Pancreatic pancreatic alkaline secretions Gastric and duodenal factors in the pathogenesis of duodenal peptic ulcers.胃 、 十 二 指 肠 结 构 及 溃 疡 病 病 因