1. 4 Cooperativity is a particular case of an allosteric effect 1. 4.1 Allosteric effect refers to the phenomenon in which a molecule(allosteric effector) bound to one site on a protein causes a conformational change in the protein such that the activity of another site on the protein is altered (increased or decreased). 1.4.2 H+, Co2, and BPg all show an allosteric effect (heterotrophic? )for the O2 binding process of hemoglobin1.4 Cooperativity is a particular case of an allosteric effect 1.4.1 Allosteric effect refers to the phenomenon in which a molecule (allosteric effector) bound to one site on a protein causes a conformational change in the protein such that the activity of another site on the protein is altered (increased or decreased). 1.4.2 H+, CO2 , and BPG all show an allosteric effect (heterotrophic?) for the O2 binding process of hemoglobin