Lab studies Quantitative serum drug concentrations are recommended for patients with serious toxicity Barbiturates: For short-acting drugs the lethal dose is 3 g or a serum concentration higher than 3.5 mg/dL. For long-acting drugs the lethal dose is 5-10 g or a concentration higher than 8 mg/dL Chloral hydrate: The lethal dose is 10 g and a concentration higher than 100 mg /mL is toxic◼ Quantitative serum drug concentrations are recommended for patients with serious toxicity ◼ Barbiturates: For short-acting drugs, the lethal dose is 3 g or a serum concentration higher than 3.5 mg/dL. For long-acting drugs, the lethal dose is 5-10 g or a concentration higher than 8 mg/dL. ◼ Chloral hydrate: The lethal dose is 10 g and a concentration higher than 100 mg/mL is toxic Lab Studies