BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Table 1. Oriented nucleation of inorganic crystals under Langmuir monolayers Monolayer Metal(mM) Mineral Nucleated face 7-10 Calcite {10 46 Vaterite CHa(CH,)1NH 4-10 Vaterite CHa(CH,),OS CH3(CH2)19PO3 CH3(CH2)17OH 4-10 Nonoriented inhibited C27HasOH 4-10 Nonoriented Baso CH3(CH2)1gOSO 0.15 B (100 CH3(CH2)1 2 0.15 Barytes (100 CHa (CH,),COo 0.15 (010) CasO a CHa(CH,)NH 2040 Gypsum (010)+{T03} CH3(CH2)( 2040 Gypsum (010)+{103} CH3(CH2)gpO 20-40 Gypsum 010)+{103} ypsum CH3(CH2)1OH 20_40 Fig. 4.23 Computer model showing side view of the calcite (110) face with Fig. 4.20 Drawing of calcite (110) crystal face with surface-adsorbed malonate o Templates used by nature Proteins polysaccharides o Process is universal for templated nucleation Material: carbonates, phosphates silica, ice Template: carboxy-rich moieties hydrogen-bonding moieties o E.g. Aspartic acid, glutamic acid, phorphorylated residues for carboxy-rich o E.g. polysaccharides, Ser, Thr for hydrogen-bonding residu (refs in Mann 1993) Lecture 12-Inorganic biomaterials 3of13BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 o Templates used by nature: ƒ Proteins ƒ Lipids ƒ polysaccharides o Process is universal for templated nucleation: ƒ Material: carbonates, phosphates silica, ice ƒ Template: carboxy-rich moieties hydrogen-bonding moieties o E.g. Aspartic acid, glutamic acid, phorphorylated residues for carboxy-rich o E.g. polysaccharides, Ser, Thr for hydrogen-bonding residues ƒ (refs in Mann 1993) Lecture 12 – Inorganic Biomaterials 3 of 13