Medical Genetics 3. Because DNa synthesis can only occu 5 to 3, a molecule of a second type of DNA polymerase (epsilon, a, in eukaryotes) binds to the other template strand as the double helix opens. This molecule must synthesize discontinuous segments of polynucleotides(okazaki fragments) Another enzyme, DNA ligase I then stitches these together into the lagging strandMedical Genetics 3. Because DNA synthesis can only occur 5' to 3', a molecule of a second type of DNA polymerase (epsilon, ε, in eukaryotes) binds to the other template strand as the double helix opens. This molecule must synthesize discontinuous segments of polynucleotides (Okazaki fragments). Another enzyme, DNA ligase I then stitches these together into the lagging strand