Eab EZogabine/Retigabine Pharmacokinetics 00 Excreted renally Carbamazepine and phenytoin decrease ezogabine Adverse effects o000oc0= Somnolence. dizziness, tremor Confusion(9%), hallucinations(2%), psychosis(1%) Urinary retention 2% QT interval prolongation KENTUCKY College of PharmacyEzogabine/Retigabine • Pharmacokinetics – Excreted renally – Carbamazepine and phenytoin decrease ezogabine • Adverse effects – Somnolence, dizziness, tremor – Confusion (9%), hallucinations (2%), psychosis (1%) – Urinary retention 2% – QT interval prolongation