Sensitization(2) Inflammatory mediators(bradykinin, prostaglands leukotrienes) can activate or sensitize primary afferents Most A-delta and C afferents innervating viscera insensitive in normal tissue. become sensitive in the case of inflammationSensitization (2) •Inflammatory mediators (bradykinin, prostaglands, leukotrienes) can activate or sensitize primary afferents •Most A-delta and C afferents innervating viscera insensitive in normal tissue, become sensitive in the case of inflammation