Learning Objectives Gain an understanding of 1. Adrenocorticoids affect both carbohydrate metabolism glucocorticoids) and modulate water balance and Na*/K transport(mineralocorticoid) 2. The nature of the stress activated pathways that control adrenocorticoid secretion 3. Structures of the major mineralo-and glucocorticoids 4. Biosynthesis of mineralo-and glucocorticoids 5. Anti-inflammatory effects of glucocorticoids and the use of pharmacological doses for treatment of inflammation 6 Structure-activity relationships for glucocorticoid activity 7. Development of synthetic glucocorticoids with reduced mineralocorticoid activity 8. Toxicity of adrenal corticoidsLearning Objectives Gain an understanding of: 1. Adrenocorticoids affect both carbohydrate metabolism (glucocorticoids) and modulate water balance and Na+ /K+ transport (mineralocorticoid) 2. The nature of the stress activated pathways that control adrenocorticoid secretion 3. Structures of the major mineralo- and glucocorticoids 4. Biosynthesis of mineralo- and glucocorticoids 5. Anti-inflammatory effects of glucocorticoids and the use of pharmacological doses for treatment of inflammation 6 Structure-activity relationships for glucocorticoid activity 7. Development of synthetic glucocorticoids with reduced mineralocorticoid activity 8. Toxicity of adrenal corticoids