Acquired syphilis (1).Primary syphilis:chancre, 1.Early regional lymphadenopathy syphilis (2).Secondary syphilis:syphilids (2 years) (3).Early latent syphilis:positive STS, without detectable clinical manifestations,normal spinal fluid 2.Late syphilis (1).Tertiary syphilis:destructive lesions (>2 years) (2).Late latent syphilis1. Early syphilis (< 2 years) 2. Late syphilis (> 2 years) (1). Primary syphilis: chancre, regional lymphadenopathy (2). Secondary syphilis: syphilids (3). Early latent syphilis: positive STS, without detectable clinical manifestations, normal spinal fluid (1). Tertiary syphilis: destructive lesions (2). Late latent syphilis Acquired syphilis