Pathogenesis Defense from reflux UES Anti-reflux barrier: LES, Diaphragm Esophagus scavenging: peristalsis, saliva Aorta left main Esophageal mucosa t bronchus Damage to esophagus Esophagus Incompetent barrier-tLESR LES Diaphragm Gastric contents www.zshospital.comwww.zshospital.com Pathogenesis Defense from reflux Anti-reflux barrier: LES, Diaphragm Esophagus scavenging : peristalsis, saliva Esophageal mucosa Damage to esophagus Incompetent barrier-tLESR Gastric contents UES Aorta left main bronchus Esophagus LES Diaphragm