3/13/2016 yersinia enterocolitica mechanisms of pathogenicity Invasive enteric (intestinal)pathogen Distal ileum(part of the intestines)is the main infection site ·Animal model studies show that after penetrating intestinal epithelial cells,the pathogen can spread to the lymph nodes and then to the blood yersinia enterocolitica virulence determinants Chromosomal virulence determinants Invasin:outer membrane protein encoded by the inv gene Related to intimin,an essential virulence determinant of EHEC Amino terminus is inserted into the outer membrane Carboxy terminus binds host cell integrins 83/13/2016 8 Yersinia enterocolitica mechanisms of pathogenicity • Invasive enteric (intestinal) pathogen • Distal ileum (part of the intestines) is the main infection site • Animal model studies show that after penetrating intestinal epithelial cells, the pathogen can spread to the lymph nodes and then to the blood Yersinia enterocolitica virulence determinants Chromosomal virulence determinants • Invasin: outer membrane protein encoded by the inv gene • Related to intimin, an essential virulence determinant of EHEC • Amino terminus is inserted into the outer membrane • Carboxy terminus binds host cell integrins Integrins