Historical Perspective Chlorpromazine(氯丙嗪) made in1950 in france, used to treat pre-operative anxiety 1952 Delay and deniker published the first report of Chlorpromazine's efficacy in psychosis 1963 Carlsson and lindqvist reported that haloperidol and Chlorpromazine result in accumulation of da metabolites D2 hypothesis(excessive dopaminergic activity plays a role in the disorder)-supported by increased dopamine receptor density and"potency'of Da antagonism at D2 related to efficacy Refs:http://www.bedrugfree.net/schizOphrenia.pdf Film: One Flew Over the Cuckoo's Nest (1975)Historical Perspective • Chlorpromazine (氯丙嗪) made in 1950 in France, used to treat pre-operative anxiety • 1952 Delay and Deniker published the first report of Chlorpromazine's efficacy in psychosis • 1963 Carlsson and Lindqvist reported that Haloperidol and Chlorpromazine result in accumulation of DA metabolites • D2 hypothesis (excessive dopaminergic activity plays a role in the disorder) – supported by increased dopamine receptor density and “potency” of DA antagonism at D2 related to efficacy. • Refs: http://www.bedrugfree.net/Schizophrenia.pdf Film: One Flew Over the Cuckoo’s Nest (1975) 9