Involvement of cytokines in the immune response Alert to Early mediators infection.tumor/etc. (IFNa/B) Recruit cells to site Chemokines (MIP- Specify type of 1o0 immune response Early late Immune effector mediators (IL-2 phase IFNy,IL-4,IL-5) Immune down- Down-regulators regulation (L-10,TNF) Immune memory Maintenance of and resetting the cytokines,etc.(GM- system CSF,IL-3,IL-7,etc.)Involvement of cytokines in the immune response ◼ Alert to infection.tumor/etc. ◼ Recruit cells to site ◼ Specify type of immune response ◼ Immune effector phase ◼ Immune down￾regulation ◼ Immune memory and resetting the system ◼ Early mediators (IFNa/b) ◼ Chemokines (MIP- 1a) ◼ Early & late mediators (IL-2, IFNg, IL-4, IL-5) ◼ Down-regulators (IL-10, TNFg) ◼ Maintenance of cytokines, etc. (GM￾CSF, IL-3, IL-7, etc.)