Pathogenesis: chronic, progressed diffuse Hepatocyte injury leading to necrosis Chronic inflammation -(hepatitis) Capillarization(肝窦毛细血管化) of the space of Disse is a key event Bridging fibrosis Regeneration of remaining hepatocytes proliferate as round nodules surrounded by fibrous septa. oss of vascular arrangement results in regenerating hepatocytes ineffective. Cirrhosis may lead to liver failure, portal hypertension, or development of hepatocellular carcinomaPathogenesis: chronic, progressed, diffuse • Hepatocyte injury leading to necrosis. • Chronic inflammation - (hepatitis). • Capillarization (肝窦毛细血管化) of the space of Disse is a key event. • Bridging fibrosis. • Regeneration of remaining hepatocytes proliferate as round nodules surrounded by fibrous septa. • Loss of vascular arrangement results in regenerating hepatocytes ineffective. • Cirrhosis may lead to liver failure, portal hypertension, or development of hepatocellular carcinoma